Key result
Early LVEF ≤30% post-MI was associated with a 40% rate of inducible VT, compared to 25% for LVEF 31-35% and 22% for LVEF 36-40% (P=0.014).
Why the study?
What is the optimal early LVEF cut-off to select patients for EPS-guided prophylactic ICD implantation after primary PCI for STEMI?
Cohort (n=1,722)
What is the optimal early LVEF cut-off to select patients for EPS-guided prophylactic ICD implantation after primary PCI for STEMI?
p-value: p=0.014
An early LVEF cut-off of ≤35% combined with inducible VT identifies post-PPCI STEMI patients at highest risk of death or arrhythmia who may derive the greatest benefit from prophylactic ICD implantation.
No takes yet. Share an insight, caveat, or question.
LVEF ≤35% may better identify high-risk ICD candidates post-PPCI; leaves open optimal thresholds pending randomized trials.
Zaman et al. (2014) conducted a cohort in ST-elevation myocardial infarction (n=1,722). Left ventricular ejection fraction (LVEF) ≤40% vs. LVEF >40% was evaluated on Inducible monomorphic ventricular tachycardia (VT) at electrophysiological study (p=0.014). Early LVEF ≤30% post-MI was associated with a 40% rate of inducible VT, compared to 25% for LVEF 31-35% and 22% for LVEF 36-40% (P=0.014).
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