Key result
Attenuated heart rate recovery and impaired endothelial function are important interacting predictors of future mortality and cardiovascular events.
Heart rate recovery and endothelial function are important interacting factors for predicting cardiovascular events and mortality.
May aid risk stratification in preventive cardiology; leaves open prospective validation and interventional trials.
An attenuated heart rate recovery immediately after exercise, thought to be a marker of reduced parasympathetic activity, has been demonstrated to be an independent predictor of all-cause mortality in several large-scale studies; however, the mechanisms by which impaired heart rate recovery confers an increased risk of death are not clear. From clinical observation, vagal reactivation was thought to be the major determinant of the decrease in heart rate during the first 30 seconds of recovery, independent of age and the intensity of exercise; however, patients with attenuated heart rate recovery were also shown to have lower exercise workload, shorter exercise duration, lower numbers achieving 90% target heart rate, and even impaired endothelial function. This review focuses on the roles of heart rate recovery and endothelial function in predicting future mortality and their interaction.
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Huang et al. (2005) conducted a review in Cardiovascular events. Attenuated heart rate recovery and impaired endothelial function was evaluated on Future mortality. Attenuated heart rate recovery and impaired endothelial function are important interacting predictors of future mortality and cardiovascular events.
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