What question did this study set out to answer?

This review aims to advance understanding of liver transplantation for hepatic malignancies by integrating biological criteria for selection and therapy.

July 30, 2026Annals of Liver TransplantationOpen Access

Advances in liver transplant oncology: Biology-driven selection, systemic therapy integration, and future trial frameworks

View Full Paper

Ask AI

Bookmark

Authors

MPMaheswaran PitchaimuthuUniversity of Oklahoma MPMaheswaran PitchaimuthuUniversity of Oklahoma

Discussion

Member takes

Implication

Review highlights advances in liver transplantation for malignancies, suggesting biology-based selection and therapy integration.

Key Points

This review aims to advance understanding of liver transplantation for hepatic malignancies by integrating biological criteria for selection and therapy.
Synthesized updated literature on hepatic malignancies including HCC, pCCA, iCCA, and others.
Reviewed outcomes of recent trials, including TransMet and VITALITY, related to liver transplantation and systemic therapy integration.
Proposed four prospective trial frameworks for future investigation in transplant oncology.
TransMet trial demonstrated 5-year overall survival of 73% with LT vs 9% with chemotherapy alone (HR 0.37, p<0.001).
VITALITY study found 75.6% of HCC patients down-staged beyond Milan criteria after ICI therapy, though with rejection rates of 17%-30%.
Mayo neoadjuvant protocol for pCCA achieved 5-year OS of 65%-82% with directed therapies showing promise in iCCA.

Cite This Study

Pitchaimuthu et al. (2026) studied this question.

synapsesocial.com/papers/6a6af4d560e2b924d3ea04bf https://doi.org/10.52604/alt.26.0006

View Full Paper

Ask AI

Bookmark

Advances in liver transplant oncology: Biology-driven selection, systemic therapy integration, and future trial frameworks

Discussion

Member takes

Implication

Key Points

Cite This Study

Advances in liver transplant oncology: Biology-driven selection, systemic therapy integration, and future trial frameworks

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider