What question did this study set out to answer?

This research aims to understand how the localization of neoantigens affects antibody-mediated tumor control and vaccine efficacy.

Endogenous neoantigen specific antibodies mediate anti-tumor responses and determine vaccine efficacy 2308188

View Full Paper

Ask AI

Bookmark

Authors

Randomized trial shows that antibody responses to neoantigens influence tumor control and vaccine efficacy, suggesting new immunotherapy strategies.

This research aims to understand how the localization of neoantigens affects antibody-mediated tumor control and vaccine efficacy.
Analyzed TCGA data for prognostic significance of intratumoral IgG.
Engineered syngeneic tumors expressing membrane-localized or cytoplasmic neoantigens to assess immune response.
Employed adenoviral vaccines to test the influence of antigen localization on vaccination outcomes.
Membrane-localized neoantigens led to increased IgG production and reduced tumor growth (p<0.05).
CXCL13 and IL-21 enhanced antibody-mediated tumor control and immune activation, providing measurable benefits.
Altered antigen localization diminished vaccine-induced tumor control despite similar T cell responses.

Sodhi et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

Randomized trial shows that antibody responses to neoantigens influence tumor control and vaccine efficacy, suggesting new immunotherapy strategies.