Key result
Lower miR-302b-3p and elevated NT-ProBNP correlate with higher hospitalization and 1-year mortality in AHF.
Why the study?
Acute heart failure is associated with high morbidity and mortality, and the diagnostic and prognostic potential of circulating miR-302b-3p and miR-103 in Egyptian adults remained to be investigated.
Do circulating levels of miR-302b-3p and miR-103 correlate with NT-proBNP and predict 1-year mortality in Egyptian adults with acute heart failure?
Case-Control (n=95)
Do circulating levels of miR-302b-3p and miR-103 correlate with NT-proBNP and predict 1-year mortality in Egyptian adults with acute heart failure?
Circulating miR-302b-3p is significantly decreased in acute heart failure, correlates inversely with NT-proBNP, and may serve as a prognostic biomarker for hospitalization and 1-year mortality.
May support miR-302b-3p as prognostic biomarker in AHF; hypothesis-generating, requiring validation before clinical adoption.
Background: Acute heart failure (AHF) is a prevalent and life-threatening condition that is associated with high morbidity and mortality, particularly in adults. MicroRNAs (miRNAs) have been identified as potential biomarkers in various cardiovascular diseases. Specifically, miR-302b-3p and miR-103 have demonstrated potential as biomarkers in heart failure. Objectives: This study aims to investigate the diagnostic and prognostic potential of circulating miR-302b-3p and miR-103 in AHF among Egyptian adults and the association between these miRNAs and NT-proBNP levels. Methods: The study involved 95 participants, comprising 45 Egyptian adults diagnosed with AHF and 50 age- and gender-matched healthy controls. Circulating levels of miR-302b-3p and miR-103 were measured using qRT-PCR, while NT-ProBNP levels were determined via enzyme-linked immunosorbent assay. Results: The expression of miR-302b-3p was significantly decreased in patients with AHF compared with healthy controls ( p < 0.05). The levels of this miRNA showed a significant negative correlation with NT-proBNP levels ( r = 0.78, p = 0.013). Lower levels of miR-302b-3p and increased NT-ProBNP levels correlated with more severe prognosis, including higher rates of hospitalization and 1-year mortality in patients with AHF ( p < 0.05). Conclusion: NT-ProBNP and miR-302b-3p serve as a promising biomarker for the diagnosis and prognosis of AHF in Egyptian adults that can further guide health care professionals for risk stratification and therapeutic response.
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Magdy et al. (2026) conducted a case-control in Acute heart failure (n=95). miR-302b-3p and NT-proBNP levels vs. Healthy controls was evaluated on 1-year mortality and hospitalization (p=< 0.05). Lower levels of miR-302b-3p and increased NT-ProBNP levels correlated with higher rates of hospitalization and 1-year mortality in patients with acute heart failure (p < 0.05).
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