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This study aims to elucidate the roles of specific transcription factors in the differentiation and maintenance of tissue-resident CD8 T cells.

Dissecting transcription factor networks for tissue-resident CD8 T cell differentiation and maintenance 2255891

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This study aims to elucidate the roles of specific transcription factors in the differentiation and maintenance of tissue-resident CD8 T cells.
Utilized CRISPR-Cas9 to delete transcription factors in CD8+ T cells across 15 tissues after LCMV infection.
Analyzed the resultant effects on T cell differentiation and phenotype in various tissue microenvironments.
KLF2 loss led to a sevenfold increase in Trm/TDRM-like CD8 T cells in the liver and SLOs post-infection.
Runx3 deletion significantly altered integrin expression, notably reducing CD103, but had minor impacts on overall Trm/TDRM establishment.
Blimp1 deletion increased recirculating memory T cells expressing CD62L with minimal effect on resident T cells.

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Randomized trial investigates transcription factor roles in CD8 T cell differentiation and maintenance, highlighting KLF2's importance.

Matson et al. (2026) studied this question.

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