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The review aims to summarize the clinical effects and safety profile of hemodiafiltration compared to hemodialysis.

July 30, 2026ToxinsOpen Access

Hemodiafiltration in Dialysis Practice: Global Adoption, Toxin Clearance, Inflammation Control, and Clinical Safety

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The review aims to summarize the clinical effects and safety profile of hemodiafiltration compared to hemodialysis.
Analysis of randomized trials and observational studies regarding hemodiafiltration use.
Evaluation of clinical benefits and safety of high-volume hemodiafiltration, particularly with convection volumes ≥23 L/session.
Assessment of challenges related to protein-bound uremic toxin clearance and micro-inflammation.
High-volume hemodiafiltration demonstrates superior removal of middle molecules compared to hemodialysis.
Evidence indicates reduced micro-inflammation and improved tolerability with hemodiafiltration.
Current data show a favorable safety profile with no consistent increased risk of complications.

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Review highlights hemodiafiltration's benefits for toxin clearance and inflammation control in dialysis, suggesting clinical advantages.

Lang et al. (2026) studied this question.

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