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July 27, 2026

Isolated rectal bleeding in neonates: a scoping review.

Alexandra Markevich Júlia Gabriely Botelho Luana Lury Morikawa Maria Angela Bellomo‐Brandão Elizete Aparecida Lomazi

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Key Points

To review the causes of isolated rectal bleeding in neonates who show no other symptoms.
Conducted a scoping review according to PRISMA guidelines
Reviewed studies of neonates up to 28 days with visible blood in stool
Selected 56 studies from initially identified 1,287 articles after screening.
Isolated rectal bleeding was diagnosed as the main condition, observed benignly in neonates.
Cow's milk protein allergy accounted for the second most frequent diagnosis in affected neonates.
22% of CMPA cases were confirmed through oral food challenges.

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Implication

Scoping review documents etiological factors of isolated rectal bleeding in asymptomatic neonates, suggesting varied causes.

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Cite This Study

Markevich et al. (2026) studied this question.

synapsesocial.com/papers/6a6af52c60e2b924d3ea0eb9 https://doi.org/10.1016/j.jped.2026.101594

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Neonatal Rectal Bleeding Due to Early‐Onset Ileocecal Intussusception: A Case ReportCase Report · 2026
2Food-Protein-Induced Proctocolitis in Pre-Term Newborns with Bloody Stools in a Neonatal Intensive Care Unit2024 · 10 citations
3Food Protein Induced Proctocolitis in Preterm Newborns with Bloody Stool in a Neonatal Intensive Care Unit2024
4Bilious Vomiting in a Neonate: A Diagnostic ChallengeOriginal Research · 2026
5A Rare Case of Cow’s Milk Protein Allergy in a 12‐Hour Old Neonate With Rectal BleedingOriginal Research · 2026

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