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July 30, 2026The Journal of Immunology

Therapeutic antigen-specific PLGA nanoparticles tolerance induces detectable changes in the spleen, blood, and disease-associate tissue 2260904

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Authors

JPJoseph PodojilACAndrew CogswellTNTobias Neef

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Overview

Randomized trial shows immune tolerance induction in mice, indicating therapeutic potential for autoimmune diseases.

Key Points

  • The aim is to explore how antigen-specific nanoparticles induce immune tolerance in CD4+ T cells to combat autoimmune diseases.
  • Utilized TCR transgenic T cells in wildtype mice
  • Primed mice with PLP139-151/CFA then treated with either unloaded or CNP-PLP139-151
  • Collected spleen, liver, CNS, and blood to quantify and phenotype T cells post treatment.
  • CNP treatment significantly decreased effector CD4+ T cells in disease-associate tissue
  • Increased the ratio of Ag-specific Tregs to IFN-γ+ cells
  • Enhanced percentages of both Ag-specific and host-derived Tregs in the blood post-treatment.

Cite This Study

Podojil et al. (2026) studied this question.

synapsesocial.com/papers/6a6af54160e2b924d3ea1216https://doi.org/10.1093/jimmun/vkag141.1002
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