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Define tumor cell states and associated microenvironmental features in colitis-associated colorectal cancer.

Spatial Multi-Platform Integration Reveals Distinct Tumor States and Microenvironmental Niches in Colitis-Associated Colorectal Cancer 2309487

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Define tumor cell states and associated microenvironmental features in colitis-associated colorectal cancer.
Analyzed seven tissue samples from three colitis-associated colorectal cancer patients.
Used 10x Xenium and 10x Visium for spatial transcriptomic analysis.
Integrated single-cell spatial coordinates with Visium spots for comprehensive analysis.
Identified two tumor cell states: proliferating (enriched for MKI67, TOP2A) and invasive (elevated CD44, CXCL1) with unique microenvironments.
Invasive regions showed enriched pathways for angiogenesis, hypoxia, and inflammation.
SPP1-CD44 signaling was identified between macrophages and invasive tumor cells.

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Randomized trial examines tumor cell states in colitis-associated colorectal cancer, suggesting new therapeutic targets.

Lee et al. (2026) studied this question.

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