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The research aims to develop a low-cost microfluidic platform for efficiently processing whole blood for point-of-care diagnostic applications.

July 30, 2026Scientific ReportsOpen Access

Microfluidic platform for rapid passive preparation of complex biological matrices in point-of-care testing

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The research aims to develop a low-cost microfluidic platform for efficiently processing whole blood for point-of-care diagnostic applications.
Utilized a microfluidic device with circular maze-shaped microchannels for passive separation of blood components.
Validated performance using HEK-293, AtT-20, mixed cell suspensions, and diluted human blood.
Integrated platform with a lateral flow immunoassay for detection of hepatitis B surface antigen.
Achieved effective cell retention, generating a cell-free filtrate suitable for analysis.
Detected hepatitis B surface antigen at concentrations as low as 10 ng/mL within 10 minutes.
Filtration efficiency and test-line intensity assessed using deep learning-assisted convolutional neural networks.

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Randomized trial demonstrates effective blood processing in point-of-care testing, suggesting improved diagnostic accessibility.

Sadighbayan et al. (2026) studied this question.

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