What question did this study set out to answer?

This research aims to understand how YY1 affects B cell lineage plasticity through various regulatory mechanisms.

YY1 regulates B cell lineage plasticity via transcriptional, miRNA post-transcriptional, and epigenetic mechanisms 2299696

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Randomized trial identifies YY1's role in B cell lineage regulation, suggesting new therapeutic targets.

This research aims to understand how YY1 affects B cell lineage plasticity through various regulatory mechanisms.
Bulk RNA-seq and scRNA-seq analyzed WT and YY1-KO pro-B cells for gene expression and chromatin accessibility.
miRNA profiles in YY1-KO pro-B cells were identified using miRDeep2 and functional enrichment was performed with clusterProfiler.
Integration of RNA-seq, miRNA, scRNA-seq, and scATAC-seq datasets constructed YY1-dependent regulatory networks.
Upregulated miRNAs in YY1-KO pro-B cells were linked to repression of B-cell signaling pathways, leading to reduced B-cell commitment.
Decreased expression of B-lineage genes such as Pla2g12a and Map3k4 was confirmed by scRNA-seq and supported by reduced chromatin accessibility.
Altered expression of downregulated miRNAs correlated with increased expression of genes promoting alternative-lineage differentiation like Cxcl2 and Il1b.

Bano et al. (2026) studied this question.

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