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September 10, 2025Journal of Clinical InvestigationOpen Access

Chromatin factor YY1 controls fetal hematopoietic stem cell migration and engraftment in mice

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Authors

SSSahitya SakaZLZhanping LuYWYinghua Wang

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Overview

Conditional deletion of YY1 impairs fetal hematopoietic stem cell migration and engraftment in bone marrow, suggesting pivotal roles in development.

Key Points

  • YY1 deletion results in neonatal lethality and reduces the fetal hematopoietic stem cell pool.
  • YY1-deficient fetal hematopoietic stem cells exhibit impaired migration and fail to establish in the adult bone marrow.
  • Genetic analysis reveals YY1 disrupts networks that regulate cell motility and adhesion in progenitor cells.
  • YY1 modulates chromatin accessibility rather than directly binding promoters of dysregulated genes.

Cite This Study

Saka et al. (2025) studied this question.

synapsesocial.com/papers/68c1b61454b1d3bfb60eb61dhttps://doi.org/10.1172/jci188140
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1YY1 in hematopoietic stem cells: epigenetic regulation, chromatin architecture, and aging2026
  2. 2Yin Yang 1 regulates cohesin complex protein SMC3 in mouse hematopoietic stem cells2024 · 13 citations
  3. 3YY1 regulates B cell lineage plasticity via transcriptional, miRNA post-transcriptional, and epigenetic mechanisms 22996962026
  4. 4Critical role of YY1 in cardiac morphogenesis2015 · 28 citations
  5. 5YY1 Expression Is Sufficient for the Maintenance of Cardiac Progenitor Cell State2017 · 17 citations