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February 19, 2015Developmental Dynamics

Critical role of YY1 in cardiac morphogenesis

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Population

Murine models during embryogenesis

Design

Preclinical

Authors

IBIlimbek BeketaevAstraZeneca (United States)
Yi Zhang
Yi ZhangRutgers, The State University of New JerseyEKEun Young KimYonsei University

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Overview

YY1 ablation causes lethal murine cardiac defects; leaves open its role in human congenital heart disease.

Structured PICO

P
Population
Murine models during embryogenesis
I
Intervention
Excision of Yin Yang 1 (YY1) using α-MHC-cre and Nkx2.5-cre activation approaches
O
Outcome
Cardiac structural formation and survival

YY1 is essential for normal cardiac morphogenesis and survival during embryogenesis, regulating endocardial cushion development and EMT.

Cite This Study

Beketaev et al. (2015) studied this question.

synapsesocial.com/papers/6a714a955d37378ac1de72eahttps://doi.org/10.1002/dvdy.24263
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Ku Protein Complex Interacts with YY1, Is Up-Regulated in Human Heart Failure, and Represses α Myosin Heavy-Chain Gene Expression2004 · 43 citations
  2. 2PIASy-Mediated Sumoylation of Yin Yang 1 Depends on Their Interaction but Not the RING Finger2007 · 88 citations
  3. 3The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation2004 · 609 citations
  4. 4High affinity YY1 binding motifs: identification of two core types (ACAT and CCAT) and distribution of potential binding sites within the human β globin cluster1995 · 144 citations