Transcription Factor Yin-Yang 1 governs cardiac metabolic reprogramming in response to exercise or pathological stress

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Cardiac-specific YY1 knockout impairs metabolic adaptation in exercise and exacerbates heart failure, suggesting key roles for transcription factors.

YY1 is essential for adaptive cardiac metabolic response, as shown by heart dysfunction in YY1 knockout mice after exercise.
Exercise enhances transcription factor networks, notably PGC-1α, while this response is blunted in YY1 KO mice.
Under pathological stress from TAC, cardiac metabolism and mitochondrial function are significantly impaired in YY1 KO mice.
YY1's interaction with epigenetic regulators p300 and HDAC3 influences cardiac energy regulation, showing different responses in exercise versus stress.

Zhang et al. (2025) studied this question.

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Cardiac-specific YY1 knockout impairs metabolic adaptation in exercise and exacerbates heart failure, suggesting key roles for transcription factors.