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July 30, 2026PLoS ONEOpen Access

“… Infections are not confined in labs…”: Community engagement for Controlled Human Infection Studies: Opinions of researchers, bioethicists and research regulators in Uganda

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Authors

WNWinfred NazziwaSNStella NeemaAEAlison M. Elliott

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Overview

Qualitative study explores opinions on community engagement for ethical controlled human infection studies in Uganda, suggesting broader participation is vital.

Key Points

  • This study aims to understand the perspectives of stakeholders on effective community engagement in controlled human infection studies.
  • Conducted a cross-sectional qualitative study involving 27 key informant interviews.
  • Participants included researchers, bioethics experts, and members of research regulatory bodies in Uganda.
  • Utilized a systematic inductive analysis approach to analyze the data.
  • Participants highlighted the need for early planning and adequate budgets for community engagement.
  • A bottom-up approach for community engagement was preferred, emphasizing respect and partnership.
  • Success in low-resource settings depends on ongoing, meaningful community involvement throughout the research process.

Cite This Study

Nazziwa et al. (2026) studied this question.

synapsesocial.com/papers/6a6af58260e2b924d3ea1f46https://doi.org/10.1371/journal.pone.0353964
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