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This research aims to understand how neoepitope-specific CD8+ T cells can effectively mediate tumor rejection and the mechanisms involved.

Activity in vivo of in vitro expanded and adoptively transferred antigen-specific CD8+ T cells against neoepitopes that mediate tumor rejection 2306826

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This research aims to understand how neoepitope-specific CD8+ T cells can effectively mediate tumor rejection and the mechanisms involved.
Antigen-specific CD8+ T cells were selected with pMHC class I tetramers.
A novel method for in vitro expansion of these T cells was utilized.
Adoptively transferred T cells were analyzed for their response and properties using flow cytometry and RNA sequencing.
Expanded CD8+ T cells against neoepitopes PDPRMUT, C3MUT, and Ccdc65cMUT led to significant tumor rejection in Meth A fibrosarcoma model.
The study demonstrated the ability of these T cells to migrate, proliferate, and exhibit functional properties post-transfer.
Insights were gained into factors that limit the efficacy of neoepitope-specific T cells and potential strategies to enhance their activity.

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Randomized trial observes tumor rejection in mice using expanded antigen-specific CD8+ T cells, highlighting potential in cancer immunotherapy.

Cheng et al. (2026) studied this question.

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Randomized trial observes tumor rejection in mice using expanded antigen-specific CD8+ T cells, highlighting potential in cancer immunotherapy.