Key result
In dogs with myxomatous mitral valve disease, a vasovagal tonus index < 6.66 discriminated stage C from B1 and B2 with 70% sensitivity and 77% specificity, and predicted a 30% higher risk of CHF.
Why the study?
Does the vasovagal tonus index (VVTI) correlate with disease severity and predict congestive heart failure in dogs with myxomatous mitral valve disease?
Observational (n=120)
Does the vasovagal tonus index (VVTI) correlate with disease severity and predict congestive heart failure in dogs with myxomatous mitral valve disease?
Effect estimate: Sensitivity 70%, Specificity 77%
In dogs with myxomatous mitral valve disease, a vasovagal tonus index < 6.66 on standard ECG is associated with advanced disease (ACVIM stage C) and a higher likelihood of developing congestive heart failure.
The vasovagal tonus index (VVTI) is a useful and assessable index, obtained from standard ECG recordings, that is used to estimate heart rate variability (HRV), and may provide valuable information regarding the likelihood of progression into congestive heart failure (CHF). In this paperwork, we investigated how the vasovagal tonus index (VVTI) behaves in dogs with naturally-occurring myxomatous mitral valve disease (MMVD) Electrocardiographic (ECG) recordings and echocardiographic data of 120 patients diagnosed with MMVD were reviewed. The VVTI was calculated from twenty consecutive RR intervals for each dog enrolled in the study. Lower VVTI values were found in MMVD patients in American College of Veterinary Internal Medicine (ACVIM) stage C compared with stages B1 and B2. Values were also lower in patients with severe cardiac remodeling. When a cut-off value of 6.66 is used, VVTI was able to discriminate MMVD patients in stage C from B1 and B2 dogs with a sensitivity of 70 per cent and a specificity of 77 per cent. MMVD dogs in which VVTI is lower than 6.66 are 30% more likely to develop congestive heart failure (CHF).
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Brüler et al. (2017) conducted an observational in Myxomatous mitral valve disease (MMVD) (n=120). Vasovagal tonus index (VVTI) < 6.66 vs. VVTI ≥ 6.66 was evaluated on Discrimination of MMVD patients in stage C from B1 and B2 dogs (Sensitivity 70%, Specificity 77%). In dogs with myxomatous mitral valve disease, a vasovagal tonus index < 6.66 discriminated stage C from B1 and B2 with 70% sensitivity and 77% specificity, and predicted a 30% higher risk of CHF.
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