What question did this study set out to answer?

The aim is to understand how monoclonal antibody treatment influences virus-specific CD4 T-cell production during Australian bat lyssavirus infection.

July 30, 2026The Journal of Immunology

Monoclonal antibody therapy augments production of virus-specific CD4 T cells during Australian bat lyssavirus infection of the CNS 2309800

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Authors

CHCeleste HuamanHenry M. Jackson Foundation JKJocelyn KingHenry M. Jackson Foundation MRMadeline RaderHenry M. Jackson Foundation

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Implication

Randomized trial finds that monoclonal antibody treatment boosts CD4 T-cell responses in ABLV-infected mice, suggesting improved therapeutic approaches.

Key Points

The aim is to understand how monoclonal antibody treatment influences virus-specific CD4 T-cell production during Australian bat lyssavirus infection.
Developed a MHC II tetramer to quantify virus-specific CD4 T-cell responses in infected mice.
Compared responses in the spleens and brains of mock-treated and monoclonal antibody-treated mice.
Used an ABLV-infection model in mice to assess immune response dynamics.
Anti-lyssavirus CD4 T-cells were detected in the spleens by day 8 and increased by day 28 in mAb-treated mice.
In mAb-treated mice, a higher frequency of CD4 T-cells was observed in the brains by day 14 compared to mock-treated mice.
Though fewer T-cells were present in mock-treated mice, those T-cells produced significantly more IFN-γ.

Cite This Study

Huaman et al. (2026) studied this question.

synapsesocial.com/papers/6a6b026860e2b924d3ea2501 https://doi.org/10.1093/jimmun/vkag141.1615

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Implication

Randomized trial finds that monoclonal antibody treatment boosts CD4 T-cell responses in ABLV-infected mice, suggesting improved therapeutic approaches.

Monoclonal antibody therapy augments production of virus-specific CD4 T cells during Australian bat lyssavirus infection of the CNS 2309800

Discussion

Member takes

Implication

Key Points

Cite This Study

Monoclonal antibody therapy augments production of virus-specific CD4 T cells during Australian bat lyssavirus infection of the CNS 2309800

Discussion

Member takes

Implication

Key Points

Cite This Study

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