Randomized trial explores binding abilities of bioactive compounds in Tetrapleura tetraptera, suggesting new therapeutic potentials.
Key Points
The aim is to analyze phytochemical compounds in Tetrapleura tetraptera fruit and evaluate their binding abilities to target proteins related to diabetes and hypertension.
Conducted gas chromatography-mass spectrometry (GC-MS) for phytochemical analysis.
Performed molecular docking using Maestro Schrodinger suite and glide tool.
Evaluated binding affinities of compounds with AMPK and eNOS receptors.
Naringenin showed greater interaction stability and stronger binding affinity with AMPK than Metformin.
Hesperidin formed more stabilizing interactions with eNOS compared to Nitroglycerine, indicating stronger binding affinity.
Twenty-six phytochemical compounds were characterized in the methanol extract of Tetrapleura tetraptera.
Cite This Study
Onwuegbuchulam et al. (2026) studied this question.