Key result
Roux-en-Y gastric bypass led to a continuous decrease in white adipose tissue inflammatory gene expression over 5 years, despite an 8 kg weight regain following an initial 38 kg weight loss.
Why the study?
Patients undergoing bariatric surgery show long-term metabolic improvements despite weight regain, and it was hypothesized these protective effects link to altered gene expression in white adipose tissue.
Does Roux-en-Y gastric bypass surgery alter long-term gene expression in white adipose tissue in obese women?
Cohort (n=78)
Does Roux-en-Y gastric bypass surgery alter long-term gene expression in white adipose tissue in obese women?
Bariatric surgery induces continuous improvements in white adipose tissue inflammatory gene expression up to 5 years post-surgery, independent of weight regain.
RYGB may sustain adipose anti-inflammatory effects beyond weight loss; extends short-term data but leaves open clinical relevance pending RCTs.
OBJECTIVE: Patients undergoing bariatric surgery present long-term metabolic improvements and reduced type 2 diabetes risk, despite long-term weight regain. We hypothesized that part of these protective effects could be linked to altered gene expression in white adipose tissue (WAT). METHODS: Transcriptomic profiling by gene microarray was performed in abdominal subcutaneous WAT from women before (n = 50) and two (n = 49) and five (n = 38) years after Roux-en-Y gastric bypass (RYGB) surgery as well as in 28 age-matched nonoperated women. RESULTS: In the obese women, the average body weight decrease was 38 kg 2 years postsurgery followed by an 8 kg weight regain between 2 and 5 years. Most of the long-term changes in WAT gene expression occurred during the first 2 years. However, a subset of genes encoding proteins involved in inflammation displayed a continued decrease between baseline, 2 and 5 years, respectively; that is an expression pattern independent of body weight regain. Expression of 71 of these genes correlated with measurements of adipocyte morphology or serum adipokine levels. CONCLUSION: The continuous improvement in WAT inflammatory gene expression, despite body weight relapse, may contribute to the sustained effects on adipose morphology after bariatric surgery.
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Kerr et al. (2020) conducted a cohort in Obesity (n=78). Roux-en-Y gastric bypass (RYGB) surgery vs. Age-matched nonoperated women and baseline measurements was evaluated on Long-term changes in white adipose tissue (WAT) gene expression. Roux-en-Y gastric bypass led to a continuous decrease in white adipose tissue inflammatory gene expression over 5 years, despite an 8 kg weight regain following an initial 38 kg weight loss.
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