Key result
Children exposed to maternal congenital heart disease were 28% more likely to demonstrate developmental vulnerability at school entry compared to unexposed children.
Why the study?
Does maternal congenital heart disease increase the risk of developmental vulnerability in offspring?
Does maternal congenital heart disease increase the risk of developmental vulnerability in offspring?
Maternal congenital heart disease is associated with an increased risk of long-term developmental vulnerability in offspring, highlighting the need for postnatal developmental monitoring.
Advances in medical and surgical treatment of congenital heart disease (CHD) now allows most affected individuals to reach adulthood and parenthood. While maternal CHD is associated with pregnancy complications, emerging evidence suggests a possible increased risk of developmental challenges in offspring, particularly among children of mothers with severe CHD.
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Leirgul et al. (2026) conducted an editorial in Maternal congenital heart disease (n=256,000). Maternal congenital heart disease vs. Unexposed children (mothers without congenital heart disease) was evaluated on Developmental vulnerability (score <10th percentile in any two of five Early Development Instrument domains) (28% more likely). Children exposed to maternal congenital heart disease were 28% more likely to demonstrate developmental vulnerability at school entry compared to unexposed children.
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