Key result
Maternal CHD severity correlates with higher neonatal morbidity and up to 3.5% mortality.
Why the study?
As more women with congenital heart disease survive to reproductive age, this study aimed to evaluate modern-era maternal and neonatal pregnancy outcomes.
Does the severity of maternal congenital heart disease impact the risk of maternal and neonatal mortality and morbidity during pregnancy?
Population
32 studies of pregnancies in women with CHD
Comparison
Mild vs moderate vs severe CHD lesions
Design
Meta-analysis
Authors
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Supports lesion-stratified counseling in maternal CHD; extends observational meta-analyses but leaves prospective validation open.
Does the severity of maternal congenital heart disease impact the risk of maternal and neonatal mortality and morbidity during pregnancy?
While pregnancy in women with congenital heart disease is generally successful, the risk of maternal morbidity and neonatal mortality increases significantly with the severity of the maternal cardiac lesion.
Hardee et al. (2021) studied this question. Neonatal mortality rates were 1%, 3.1%, and 3.5% for mild, moderate, and severe CHD lesions, respectively, with increased morbidity correlated to lesion severity.