Key result
Adenosine-assisted intracranial aneurysm surgery was not significantly associated with increased 30-day mortality or cardiac complications (adjusted OR 2.12; 95% CI 0.76-5.93; P=0.15).
Why the study?
Does intraoperative adenosine administration increase the risk of 30-day mortality or perioperative cardiac complications in patients undergoing intracranial aneurysm surgery?
Cohort (n=326)
Does intraoperative adenosine administration increase the risk of 30-day mortality or perioperative cardiac complications in patients undergoing intracranial aneurysm surgery?
Odds Ratio: 2.12 (95% CI 0.76–5.93)
Absolute Event Rate: 9.4% vs 4.6%
p-value: p=0.15
Adenosine-induced flow arrest during intracranial aneurysm surgery appears safe and is not associated with a significant increase in perioperative cardiac complications or 30-day mortality in patients with a low risk of coronary artery disease.
No takes yet. Share an insight, caveat, or question.
Supports short-term safety of adenosine in aneurysm surgery; leaves open need for prospective confirmation.
Khan et al. (2013) conducted a cohort in Intracranial aneurysm (n=326). Adenosine-induced flow arrest vs. No adenosine was evaluated on Composite of 30-day mortality and incidences of perioperative cardiac complications (perioperative myocardial infarction or perioperative cardiac arrhythmias) (adjusted OR 2.12, 95% CI 0.76-5.93, p=0.15). Adenosine-assisted intracranial aneurysm surgery was not significantly associated with increased 30-day mortality or cardiac complications (adjusted OR 2.12; 95% CI 0.76-5.93; P=0.15).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: