Key result
Fetuses of women with well-controlled insulin-dependent diabetes had increased abdominal subcuticular thickness at 37 weeks compared to controls (5.6 vs 4.8 mm, P<0.05).
Why the study?
Does well-controlled insulin-dependent diabetes in pregnancy increase fetal adipose tissue deposition compared to normal pregnancies?
Population
n=31 pregnant women, comprising 15 well-controlled insulin-dependent women with diabetes and 16 controls…
Comparison
Well-controlled insulin-dependent diabetes… vs Normal glucose pregnancies
Design
Cohort
Follow-up
From 31 weeks gestation to birth
Authors
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Even well-controlled insulin-dependent diabetes was associated with greater fetal subcutaneous fat; leaves open causal contribution to macrosomia and needs prospective validation.
Observational (n=31)
Does well-controlled insulin-dependent diabetes in pregnancy increase fetal adipose tissue deposition compared to normal pregnancies?
Absolute Event Rate: 5.6% vs 4.8%
p-value: p=<0.05
Fetuses of women with well-controlled insulin-dependent diabetes have increased adipose tissue deposition compared to normal pregnancies, potentially explaining the persistent risk of macrosomia.
Greco et al. (2003) conducted an observational in Pregnancy with insulin-dependent diabetes (n=31). Well-controlled insulin-dependent diabetes vs. Normal glucose was evaluated on Abdominal subcuticular thickness at 37 weeks (p=<0.05). Fetuses of women with well-controlled insulin-dependent diabetes had increased abdominal subcuticular thickness at 37 weeks compared to controls (5.6 vs 4.8 mm, P<0.05).
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