Key result
Maternal exercise and apelin administration enhanced fetal brown adipose tissue development and prevented obesity in offspring mice challenged with a high-energy diet.
Why the study?
Does maternal exercise or apelin administration prevent metabolic dysfunction and obesity in offspring mice?
Does maternal exercise or apelin administration prevent metabolic dysfunction and obesity in offspring mice?
Maternal exercise or apelin administration during pregnancy enhances fetal brown adipose tissue development and protects offspring from diet-induced obesity.
Hypothesis-generating for maternal exercise in human pregnancy; leaves open clinical translation from murine models.
promoter and BAT development and prevented obesity of offspring when challenged with a high-energy diet. Apelin, an exerkine, was elevated in both maternal and fetal circulations due to exercise, and maternal administration of apelin mimicked the beneficial effects of exercise on fetal BAT development and offspring metabolic health. Together, maternal exercise enhances thermogenesis and the metabolic health of offspring mice, suggesting that the sedentary lifestyle during pregnancy contributes to the obesity epidemic in modern societies.
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Son et al. (2020) studied Obesity and metabolic dysfunction. Maternal exercise and apelin administration vs. Sedentary lifestyle / no apelin was evaluated on Brown adipose tissue (BAT) development and obesity prevention. Maternal exercise and apelin administration enhanced fetal brown adipose tissue development and prevented obesity in offspring mice challenged with a high-energy diet.
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