Key result
Advanced age in F344xBN rats shifted the tension-pCa curve (5.66 vs 5.78 pCa units) and increased time to peak sarcomere shortening (58.9 vs 50.5 ms) without altering relaxation.
Why the study?
Does aging alter single cardiac myocyte function in Fischer 344 x Brown Norway rats?
Population
Isolated cardiac myocytes from female Fischer 344 x Brown Norway rats at 6 and 32-33 months of age
Comparison
Advanced age (32-33 months) vs Young age (6 months)
Design
Preclinical
Authors
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Age-related myofilament shifts without relaxation impairment in this model; leaves open compensatory mechanisms across strains and human translation.
Does aging alter single cardiac myocyte function in Fischer 344 x Brown Norway rats?
Absolute Event Rate: 5.66% vs 5.78%
Aging in F344xBN rat cardiac myocytes primarily causes a shift in the myosin heavy chain isoform without directly altering relaxation, suggesting that relaxation changes seen in other strains may be due to compensatory mechanisms from age-related pathology.
Wahr et al. (2000) studied Aging. Advanced age (32-33 months) vs. Young age (6 months) was evaluated on Tension-pCa curve. Advanced age in F344xBN rats shifted the tension-pCa curve (5.66 vs 5.78 pCa units) and increased time to peak sarcomere shortening (58.9 vs 50.5 ms) without altering relaxation.
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