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July 1, 1993AJP Heart and Circulatory Physiology

Normal and hypertrophied senescent rat heart: mechanical and molecular characteristics

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Population

Senescent rats, young adult rats, and senescent deoxycorticosterone acetate-salt rats

Comparison

Aging and pressure overload vs Young adult rats and normal senescent rats

Design

Preclinical

Authors

SBSophie BesseInsermPAPatrick AssayagUniversité Paris-SaclayCDClaude DelcayreInserm

Discussion

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Implication

Senescence impairs rat myocardial velocity akin to pressure overload; leaves open translation to human age-related HF mechanisms.

Structured PICO

P
Population
Senescent (S) rats, young adult (YA) rats, and senescent deoxycorticosterone acetate (DOCA)-salt rats (pressure overload model)
I
Intervention
Aging (senescence) and pressure overload (DOCA-salt)
C
Comparator
Young adult rats (for aging comparison) and normal senescent rats (for pressure overload comparison)
O
Outcome
Cardiac mechanical properties (economy of contraction, maximum unloaded shortening velocity [Vmax], active tension) and molecular characteristics (alpha-MHC, beta-MHC, and SR Ca2+-ATPase mRNA contents)surrogate

Senescence modifies cardiac mechanics and gene expression in a manner similar to pressure overload, and additional pressure overload in senescent hearts further attenuates shortening velocity without worsening contraction economy.

Cite This Study

Besse et al. (1993) studied this question.

synapsesocial.com/papers/6a71466e2163a0a01bc56e81https://doi.org/10.1152/ajpheart.1993.265.1.h183
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Senescent Heart Compared With Pressure Overload–Induced Hypertrophy1997 · 58 citations
  2. 2Mechanical properties of myocardium from hypertrophied rat hearts. A comparison between hypertrophy induced by senescence and by aortic banding.1980 · 95 citations
  3. 3Effect of aging and hypertension on myosin biochemistry and gene expression in the rat heart.1991 · 67 citations
  4. 4Arrhythmogenicity of the hypertrophied and senescent heart and relationship to membrane proteins involved in the altered calcium handling1993 · 23 citations
  5. 5Cardiac dysfunction in aging conscious rats: altered cardiac cytoskeletal proteins as a potential mechanism2008 · 18 citations