Key result
Hypertensive hypertrophy prolongs shortening and relaxation times but preserves shortening velocity.
Why the study?
It was uncertain whether cardiac dysfunction is a general property of pressure hypertrophied myocardium or specific to particular animal models of pressure overload.
Population
Adult and aged spontaneously hypertensive rats and adult cats with pressure overload
Comparison
Left ventricular pressure overload in rats vs right ventricular pressure overload in cats
Design
Comparative animal model study with chronic progressive pressure overload
Follow-up
1 and 2 years in rats; duration not specified for cats
Authors
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Animal model differences in hypertrophy responses caution against broad extrapolation; leaves open which models best inform human pressure-overload disease.
Robert J. Tomanek (1987) studied Pressure hypertrophied myocardium (n=28). Chronic progressive cardiac pressure overload (spontaneous hypertension) vs. Normotensive controls was evaluated on Cardiac muscle mechanics (extent and velocity of shortening, relaxation times, developed tension, oxygen consumption). Pressure-induced hypertrophy in spontaneously hypertensive rats showed prolonged shortening and relaxation times but preserved shortening velocity, contrasting with previous cat models.
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