Population
female Wistar rats
Design
Preclinical
Follow-up
30 weeks
Authors
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Does not support clinical translation; leaves open whether hypertrophy preserves force at velocity's expense in human hypertension.
In a rat model of gradual onset hypertension, myocardial hypertrophy maintains ventricular force development while the speed of shortening decays.
Capasso et al. (1981) studied this question.
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