Why the study?
Does induced Goldblatt hypertension alter the mechanical properties and wall dimensions of thoracic aortas in male Wistar rats?
Population
Male Wistar rats aged 8 to 9 weeks
Design
Preclinical
Follow-up
2, 4, 8, or 16 weeks
Authors
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Rapid aortic thickening may normalize wall stress before elastic changes in hypertension; hypothesis-generating in rats, human translation unproven.
Does induced Goldblatt hypertension alter the mechanical properties and wall dimensions of thoracic aortas in male Wistar rats?
In response to hypertension, aortic wall dimensional changes (thickening) occur much earlier than changes in elastic properties to maintain constant wall stress.
MATSUMOTΟ et al. (1994) studied this question.
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