Population
Rat thoracic aorta
Comparison
Goldblatt hypertension induced by constricting… vs Normotensive control aortas
Design
Preclinical
Follow-up
8 weeks
Authors
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Aortic adaptation to hypertension appears primarily circumferential; leaves open translation to human disease and clinical relevance.
The aortic wall adapts to hypertension-induced mechanical stress primarily by changing wall dimensions and residual stresses in the circumferential direction, driven by smooth muscle cell hypertrophy.
MATSUMOTΟ et al. (1996) studied this question.
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