Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 1, 1974Acta Physiologica Scandinavica

Rate and Extent of Adaptive Cardiovascular Changes in Rats during Experimental Renal Hypertension

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does renal artery constriction induce cardiovascular structural adaptation in normotensive male Wistar rats?

Population

Normotensive male Wistar rats

Comparison

Renal artery constriction to induce renal… vs Normotensive control rats

Design

Preclinical

Follow-up

4.5 months

Authors

YLYen LundgrenSahlgrenska University HospitalMHMargareta HallbäckStockholm Health Care ServicesLWLilian WeissTriemli Hospital

Discussion

Loading...

Member takes

Implication

Sequential remodeling in rat renal hypertension is hypothesis-generating; leaves open translation to human renovascular disease.

Structured PICO

Does renal artery constriction induce cardiovascular structural adaptation in normotensive male Wistar rats?

P
Population
Normotensive male Wistar rats
I
Intervention
Renal artery constriction to induce renal hypertension
C
Comparator
Normotensive control rats
O
Outcome
Hemodynamic characteristics, extent of left ventricular hypertrophy, and water content of the aortic wall at different intervals up to 4.5 monthssurrogate

Experimental renal hypertension in rats induces rapid left ventricular and vascular media hypertrophy within weeks, followed by late-phase arterial water logging.

Cite This Study

Lundgren et al. (1974) studied this question.

synapsesocial.com/papers/6a6f9be835aa2c282ce0f39chttps://doi.org/10.1111/j.1748-1716.1974.tb05662.x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vascular Reactivity in Post-Deoxycorticosterone Hypertension in Rats and its Relation to ‘Irreversible’ Hypertension in Man1972 · 17 citations
  2. 2Time Course and Extent of Structural Vascular Adaptation to Regional Hypotension in Adult Spontaneously Hypertensive Rats (SHR)1974 · 23 citations
  3. 3The Effects of “Immunosympathectomy” on Blood Pressure and Vascular “Reactivity” in Normal and Spontaneously Hypertensive Rats1972 · 73 citations
  4. 4Long‐term Treatment with Antihypertensive Drugs in Spontaneously Hypertensive Rats (SHR). Effects on Blood Pressure, Survival Rate and Cardiovascular Design1974 · 47 citations
  5. 5The Distensibility of the Resistance Vessels in Spontaneously Hypertensive Rats (SHR) as Compared with Normotensive Control Rats (NCR)1974 · 29 citations