Population
24-month-old and 4-month-old rats
Comparison
Renovascular hypertension vs Normotensive 24-month-old and 4-month-old rats
Design
Preclinical
Authors
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Retained hypertrophic adaptations in aged rat myocardium warrant no clinical change; leaves open translation to elderly humans with hypertension.
The aged rat myocardium retains the ability to undergo molecular and biochemical hypertrophic adaptations in response to a superimposed pressure load, similar to younger animals.
Buttrick et al. (1991) studied this question.
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