Age-related differences in the expression of proto-oncogene and contractile protein genes in response to pressure overload in the rat myocardium.
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Population
Adult (9-month-old) and old (18-month-old) rats
Comparison
Ascending aortic constriction to induce pressure… vs Comparison between adult and old rats subjected…
Design
Preclinical
Follow-up
Up to 5 days post-operation
Authors
Discussion
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Implication
Suggests molecular basis for greater HF susceptibility after pressure overload in aging; leaves open human relevance and therapeutic implications.
Structured PICO
P
Population
Adult (9-month-old) and old (18-month-old) rats
I
Intervention
Ascending aortic constriction (AoC) to induce pressure overload
C
Comparator
Comparison between adult and old rats subjected to similar hemodynamic stress
O
Outcome
Ventricular expression of proto-oncogenes (c-fos, c-jun) and contractile protein genes (beta- to alpha-MHC, SERCA, calsequestrin, ANF, skeletal alpha-actin)surrogate
Aged rats exhibit a blunted proto-oncogene response and maladaptive contractile protein gene expression following acute pressure overload, which may contribute to their higher susceptibility to heart failure.
Cite This Study
Takahashi et al. (1992) studied this question.
Topics
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