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January 1, 1997HypertensionOpen Access

Senescent Heart Compared With Pressure Overload–Induced Hypertrophy

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Why the study?

Does aging or renovascular hypertension alter left ventricular function and calcium-regulating protein mRNA levels in rats?

Population

Rats, including 4-month-old adults and 24-month-old senescent rats. For renovascular hypertension, rats were…

Comparison

Aging and induction of renovascular hypertension vs Adult rats and sham-operated controls

Design

Preclinical

Follow-up

2 months (for renovascular hypertension model)

Authors

PAPatrick AssayagUniversité Paris-SaclayDCDanièle CharlemagneUniversité Claude Bernard Lyon 1JLJoël de LeirisTranslational Innovation in Medicine and Complexity

Discussion

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Implication

Should not alter hypertension management in the elderly; leaves open translational relevance of SERCA2 changes in human cardiac aging.

Structured PICO

Does aging or renovascular hypertension alter left ventricular function and calcium-regulating protein mRNA levels in rats?

P
Population
Rats, including 4-month-old adults (n=13 for mRNA/hemodynamics, n=11 for ex vivo) and 24-month-old senescent rats (n=15 for mRNA/hemodynamics, n=11 for ex vivo). For renovascular hypertension, rats were operated at 2 months (n=11 hypertension, n=6 sham) and 22 months (n=26 hypertension, n=5 sham) of age.
I
Intervention
Aging (senescence at 24 months) and induction of renovascular hypertension
C
Comparator
Adult rats (4 months old) and sham-operated controls
O
Outcome
Hemodynamics, ex vivo active tension, and mRNA levels of Na(+)-Ca2+ exchanger (NCx), ryanodine receptor (RyR2), and sarcoplasmic reticular Ca2+ ATPase (SERCA2)surrogate

Senescence in rats is associated with ex vivo contractile dysfunction and decreased SERCA2 mRNA levels despite normal in vivo resting LV function, and aged rats exhibit 100% mortality in response to renovascular hypertension.

Cite This Study

Assayag et al. (1997) studied this question.

synapsesocial.com/papers/6a71466e2163a0a01bc56e7dhttps://doi.org/10.1161/01.hyp.29.1.15
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of aging and hypertension on myosin biochemistry and gene expression in the rat heart.1991 · 67 citations
  2. 2Mechanical properties of myocardium from hypertrophied rat hearts. A comparison between hypertrophy induced by senescence and by aortic banding.1980 · 95 citations
  3. 3Function of the sarcoplasmic reticulum and expression of its Ca2(+)-ATPase gene in pressure overload-induced cardiac hypertrophy in the rat.1990 · 341 citations
  4. 4Age-related alterations in the phosphorylation of sarcoplasmic reticulum and myofibrillar proteins and diminished contractile response to isoproterenol in intact rat ventricle.1993 · 87 citations
  5. 5Cardiac adaptations to aortic constriction in adult and aged rats1989 · 22 citations