Key result
The calcium pump of cardiac sarcoplasmic reticulum is regulated by the phosphorylation status of phospholamban, a homopentamer whose oligomeric structure may provide functional advantages in pump control.
This review highlights the specific role of the pentameric structure of phospholamban in regulating the cardiac sarcoplasmic reticular calcium pump.
No takes yet. Share an insight, caveat, or question.
Pentameric phospholamban may confer regulatory advantages; extends molecular insights into SR calcium handling but leaves clinical translation open.
John Colyer (1993) conducted a review in Cardiac muscle contraction and calcium handling. Phospholamban was evaluated. The calcium pump of cardiac sarcoplasmic reticulum is regulated by the phosphorylation status of phospholamban, a homopentamer whose oligomeric structure may provide functional advantages in pump control.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: