Key result
The combination of thrombin and CD40L synergistically increased endothelial MMP-10 mRNA (5-fold; P<0.001) and protein levels (4.5-fold; P<0.001) compared to either stimulus alone.
Effect estimate: 5-fold increase in mRNA, 4.5-fold increase in protein
p-value: p=<0.001
Thrombin and CD40L synergistically increase endothelial MMP-10 expression and microparticle generation, linking inflammation and thrombosis.
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May link thrombosis-inflammation via endothelial MMP-10 in sepsis; hypothesis-generating for targeted interventions.
Lizarrondo et al. (2012) studied Sepsis with systemic inflammation (n=60). Thrombin and CD40 Ligand combination vs. Either stimulus alone was evaluated on MMP-10 mRNA and protein levels (5-fold increase in mRNA, 4.5-fold increase in protein, p=<0.001). The combination of thrombin and CD40L synergistically increased endothelial MMP-10 mRNA (5-fold; P<0.001) and protein levels (4.5-fold; P<0.001) compared to either stimulus alone.
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