May 15, 2010AJP Heart and Circulatory Physiology
Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects
Key result
Lysyl oxidase upregulation and overactivity are associated with increased collagen cross-linking and stiffness, contributing to myocardial fibrosis and altered left ventricular mechanics.
Design
Review
Authors
Discussion
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Implication
Myocardial fibrosis from persistent injury may drive adverse remodeling; leaves open targeted antifibrotic strategies for future trials.
PICO
P
Population
Myocardial fibrosis and heart failure
E
Exposure / Comparator
Lysyl oxidase (LOX)
This review highlights the role of lysyl oxidase in myocardial fibrosis and its potential as a therapeutic target in heart failure.
Cite This Study
López et al. (2010) conducted a review in Myocardial fibrosis and heart failure. Lysyl oxidase (LOX) was evaluated. Lysyl oxidase upregulation and overactivity are associated with increased collagen cross-linking and stiffness, contributing to myocardial fibrosis and altered left ventricular mechanics.