Key result
Carrying 3 predicted risk genotypes in adrenergic receptor-related genes significantly increased the risk of cardiovascular events in patients with dilated cardiomyopathy (RR 3.47).
Why the study?
Does carrying 3 predicted risk genotypes in adrenergic receptor-related genes increase the risk of cardiovascular events in patients with idiopathic dilated cardiomyopathy?
Cohort (n=83)
Blinded assessment
No
Does carrying 3 predicted risk genotypes in adrenergic receptor-related genes increase the risk of cardiovascular events in patients with idiopathic dilated cardiomyopathy?
Relative Risk: 3.47 (95% CI 1.25–9.62)
Absolute Event Rate: 55.6% vs 20.3%
p-value: p=0.017
Carrying three specific adrenergic receptor-related risk genotypes is associated with worse cardiovascular event-free survival in patients with idiopathic dilated cardiomyopathy.
Authors
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Associated with higher event risk in idiopathic dilated cardiomyopathy; leaves open whether genotyping refines prognostication.
Ogimoto et al. (2012) conducted a cohort in Dilated Cardiomyopathy (DCM) (n=83). 3 predicted risk genotypes (ADRB1 Ser49 carrier, ADRB1 Arg389 carrier, and NET-182CC) vs. Fewer than 3 predicted risk genotypes was evaluated on Cardiovascular events (cardiac death and emergent hospitalization due to heart failure, arrhythmia, or cerebrovascular events) (RR 3.47, 95% CI 1.25-9.62, p=0.017). Carrying 3 predicted risk genotypes in adrenergic receptor-related genes significantly increased the risk of cardiovascular events in patients with dilated cardiomyopathy (RR 3.47).
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