Reduced lipoprotein (a) in patients with severe hypertriglyceridaemia

Figures

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  Figure 1.. Flow chart showing patient selection and classification in a case–control study that evaluated the relationship between plasma lipoprotein (a) (Lp[a]) and triglyceride (TG) in a cohort of individuals with severe hypertriglyceridaemia (HTG) who were all molecularly characterized. The inclusion criteria consisted of available Lp(a) levels and a clinical diagnosis of severe HTG with TG >10 mmol/l. Each patient was assessed for monogenic variants and their polygenic risk score (PRS) was calculated. PRS was unavailable in two patients.

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  Figure 2.. Distribution of transformed lipoprotein (a) (Lp[a]) levels in patients with severe hypertriglyceridaemia (HTG) (blue, n = 154) and healthy control subjects (green, n = 272). Data were transformed using the natural logarithm in order to visualize the two skewed distributions more clearly. Lp(a) levels are divided into groups of 5 mg/dl and the frequency of each group is displayed as a proportion of the total cohort. The colour version of this figure is available at: http://imr.sagepub.com.

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  Figure 3.. The relationship between lipoprotein (a) (Lp[a]) and triglyceride (TG) levels in patients with severe hypertriglyceridaemia (HTG) (blue, n = 154) and healthy control subjects (green, n = 267) was evaluated: (A) shows untransformed values; and (B) shows the same data with natural logarithmic transformation. For both figures, a linear trendline, Pearson correlation coefficient and correlational P-value are displayed above for the severe HTG (r = −0.072; P = 0.375) and control cohorts (r = −0.038; P = 0.531). TG were transformed using the natural logarithm to minimize the gap between cohorts and make the x-axis more accessible for viewing. Original TG levels are shown in mmol/l. The colour version of this figure is available at: http://imr.sagepub.com.

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  Figure. 4.. The relationships between lipoprotein (a) (Lp[a]) and apolipoprotein B (apo B) and Lp(a) and non-high-density lipoprotein cholesterol (non-HDL-C) (B) levels in patients with severe hypertriglyceridaemia (HTG) and healthy control subjects: (A) the relationship between Lp(a) and apo B in patients with severe HTG (blue, n = 142) and control subjects (green, n = 257) was evaluated. A linear trendline, Pearson correlation coefficient and correlational P-value are displayed above the severe HTG (r = 0.235; P = 0.005) and control cohorts (r = 0.175; P = 0.005); (B) the relationship between Lp(a) and non-HDL-C in patients with severe HTG (blue, n = 154) and control subjects (green, n = 272) was evaluated. A linear trendline, Pearson correlation coefficient and correlational P-value are displayed above the severe HTG (r = −0.058; P = 0.473) and control cohorts (r = 0.064; P = 0.290). The colour version of this figure is available at: http://imr.sagepub.com.