Key result
Common genetic variants associated with mild triglyceride variation, including SNPs in APOA5, APOE, GCKR, TRIB1, and TBL2/MLXIPL, were significantly associated with severe hypertriglyceridemia.
Population
132 patients of European ancestry with severe hypertriglyceridemia who had no mutations found by…
Comparison
Genotyping for common SNPs associated with mild… vs 351 matched normolipidemic controls
Design
Case-control
Authors
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Common TG variants associate with severe HTG after excluding rare mutations; extends GWA findings to extremes but leaves clinical utility open.
Case-Control (n=483)
Common genetic variants associated with mild triglyceride elevations also contribute significantly to the risk of severe hypertriglyceridemia, supporting a polygenic model for the condition.
Wang et al. (2008) conducted a case-control in Severe hypertriglyceridemia (n=483). Common genetic variants (SNPs) associated with mild TG variation vs. Normolipidemic controls was evaluated on Severe hypertriglyceridemia. Common genetic variants associated with mild triglyceride variation, including SNPs in APOA5, APOE, GCKR, TRIB1, and TBL2/MLXIPL, were significantly associated with severe hypertriglyceridemia.
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