July 1, 1995Arteriosclerosis Thrombosis and Vascular Biology
Multiple Genetic Determinants of Variation of Plasma Lipoproteins in Alberta Hutterites
Key result
Variation in nine candidate genes accounted for 3.2% to 7.8% of the total variation in fasting plasma lipoproteins among 718 normolipemic Alberta Hutterites.
Why the study?
Are variations in candidate genes associated with fasting plasma lipoprotein levels in a genetic isolate population?
Population
718 Alberta Hutterites, a normolipemic human genetic isolate
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Requires replication in diverse populations; leaves open clinical relevance for lipoprotein trait genetics.
Study Design
Type
Observational (n=718)
Structured PICO
Are variations in candidate genes associated with fasting plasma lipoprotein levels in a genetic isolate population?
P
Population
718 normolipemic Alberta Hutterites evaluated for the association between candidate gene variations and fasting plasma lipoprotein variables.
E
Exposure
Genotypes of nine candidate genes in lipoprotein metabolism (APOB, PON, LPL, VLDLR, APOC3, LRP, HL, LDLR, APOE)
O
Outcome
Variation in fasting plasma lipoprotein variables (plasma lipids, lipoproteins, and apolipoproteins)surrogate
Main Result
Effect estimate: 3.2% to 7.8% of total variation explained
Variation in candidate genes accounts for a modest but significant portion (3.2-7.8%) of the variation in plasma lipoprotein levels in a normolipemic genetic isolate.
Cite This Study
Hegele et al. (1995) conducted an observational in Normolipemic (n=718). Variation of nine candidate genes in lipoprotein metabolism was evaluated on Variation in fasting plasma lipoprotein variables (3.2% to 7.8% of total variation explained). Variation in nine candidate genes accounted for 3.2% to 7.8% of the total variation in fasting plasma lipoproteins among 718 normolipemic Alberta Hutterites.