A gene-gender interaction affecting plasma lipoproteins in a genetic isolate.
Key result
ApoE and LPL genotypes were significantly associated with plasma lipoproteins, with apoE affecting apoB-related traits in men and LPL affecting them in women.
Why the study?
Are variations in apoE and LPL genes associated with fasting plasma lipoproteins in a genetic isolate, and does sex affect this association?
Population
803 Hutterites
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Findings in genetic isolates should not yet alter lipid management; leaves open generalizability to broader populations.
Study Design
Type
Observational (n=803)
Structured PICO
Are variations in apoE and LPL genes associated with fasting plasma lipoproteins in a genetic isolate, and does sex affect this association?
P
Population
803 individuals from the Hutterite Brethren genetic isolate evaluated for associations between apoE and LPL genotypes and fasting plasma lipoproteins.
E
Exposure
Variation in apolipoprotein (apo) E and lipoprotein lipase (LPL) genes
O
Outcome
Fasting plasma lipoproteins (total cholesterol, LDL cholesterol, apoB, triglycerides)surrogate
Genetic variations in apoE and LPL have sex-specific effects on plasma lipoprotein profiles in a genetic isolate.
Cite This Study
Hegele et al. (1994) conducted an observational in Plasma lipoprotein variation (n=803). Apolipoprotein E (apoE) and lipoprotein lipase (LPL) genotypes was evaluated on Fasting plasma lipoproteins (total cholesterol, LDL cholesterol, apoB, triglycerides). ApoE and LPL genotypes were significantly associated with plasma lipoproteins, with apoE affecting apoB-related traits in men and LPL affecting them in women.