November 1, 1999
Analysis of lipoprotein lipase haplotypes reveals associations not apparent from analysis of the constituent loci.
Why the study?
Does haplotype analysis of the LPL gene reveal associations with plasma lipid levels and LPL activity not apparent from single-locus genotype analysis in males with coronary atherosclerosis?
Population
807 Dutch males with coronary atherosclerosis
Comparison
Haplotype analysis of 3 loci in the lipoprotein… vs Genotype analysis of constituent loci separately
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Haplotype associations with lipids and LPL activity remain hypothesis-generating; larger prospective studies needed before any clinical consideration.
Structured PICO
Does haplotype analysis of the LPL gene reveal associations with plasma lipid levels and LPL activity not apparent from single-locus genotype analysis in males with coronary atherosclerosis?
P
Population
807 Dutch males with coronary atherosclerosis
I
Intervention
Haplotype analysis of 3 loci (PvuII, HindIII, and Ser 447 -Stop) in the lipoprotein lipase (LPL) gene
C
Comparator
Genotype analysis of constituent loci separately
O
Outcome
Plasma lipid levels (total cholesterol, triglycerides) and LPL activitysurrogate
Haplotype analysis of the LPL gene provides more detailed insights into its effects on lipid levels and enzyme activity than single-locus genotype analysis in patients with coronary atherosclerosis.
Cite This Study
Hallman et al. (1999) studied this question.