Why the study?
Does LPL haplotype 19-4 influence post-heparin plasma LPL activity and metabolic syndrome phenotypes in Mexican-Americans?
Population
847 subjects from 163 families in the Mexican-American Coronary Artery Disease Project cohort
Comparison
LPL haplogenotype (specifically haplotype 19-4) vs Other LPL haplotypes
Design
Cohort
Authors
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Should not yet change metabolic syndrome management; extends LPL genetic associations in Mexican-Americans but leaves causal role open.
Does LPL haplotype 19-4 influence post-heparin plasma LPL activity and metabolic syndrome phenotypes in Mexican-Americans?
Variation in the 3' untranslated region of the LPL gene is associated with altered LPL activity and metabolic syndrome phenotypes in Mexican-Americans.
Goodarzi et al. (2005) studied this question.
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