March 1, 1993Journal of Lipid ResearchOpen Access

Two DNA polymorphisms in the lipoprotein lipase gene and their associations with factors related to cardiovascular disease.

View Full Paper

Ask AI

Bookmark

Population

1,194 diabetic and non-diabetic Hispanics and non-Hispanic Whites from the San Luis Valley, Colorado.

Comparison

HindIII and PvuII polymorphisms in the… vs Comparison between different genotypes

Design

Cross-sectional

Authors

YAY I AhnUniversity of Pittsburgh MKM. Ilyas KambohUniversity of Pittsburgh RHRichard F. HammanColorado School of Public Health

Discussion

Member takes

Implication

LPL HindIII variant associated with triglyceride levels across groups; hypothesis-generating for genetic lipid research, no practice change.

Structured PICO

Population

1,194 diabetic and non-diabetic Hispanics and non-Hispanic Whites from the San Luis Valley, Colorado (Hispanics: 195 diabetic, 384 non-diabetic; non-Hispanic Whites: 76 diabetic, 539 non-diabetic).

Intervention

HindIII and PvuII polymorphisms in the lipoprotein lipase (LPL) gene

Comparator

Comparison between different genotypes (e.g., -/-, +/-, +/+)

Outcome

Plasma levels of total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, fasting glucose, and fasting insulinsurrogate

The HindIII polymorphism in the LPL gene is significantly associated with variations in plasma triglyceride and HDL-cholesterol levels, demonstrating a clear gene dosage effect.

Cite This Study

Ahn et al. (1993) studied this question.

synapsesocial.com/papers/6a70adff660549caf2c54ea1 https://doi.org/10.1016/s0022-2275(20)40733-3

Topics

Women and heart disease

View Full Paper

Ask AI

Bookmark

Implication

LPL HindIII variant associated with triglyceride levels across groups; hypothesis-generating for genetic lipid research, no practice change.

Two DNA polymorphisms in the lipoprotein lipase gene and their associations with factors related to cardiovascular disease.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Two DNA polymorphisms in the lipoprotein lipase gene and their associations with factors related to cardiovascular disease.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider