Why the study?
Does the (+/+) lipoprotein lipase-HindIII genotype associate with the clustering of insulin-resistance syndrome components in normoglycemic individuals?
Population
890 normoglycemic individuals (370 Hispanics and 520 non-Hispanic whites) from the San Luis Valley, Colorado
Comparison
lipoprotein lipase-HindIII restriction of… vs (+/-) lipoprotein lipase-HindIII genotype
Design
Cross-sectional
Authors
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Should not yet guide genotyping in normoglycemic patients; leaves open causal role of LPL-HindIII in insulin-resistance clustering.
Does the (+/+) lipoprotein lipase-HindIII genotype associate with the clustering of insulin-resistance syndrome components in normoglycemic individuals?
The (+/+) lipoprotein lipase-HindIII genotype is significantly associated with the clustering of insulin-resistance syndrome components, representing a potential genetic basis for metabolic risk.
Ahn et al. (1993) studied this question.
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