January 1, 1993Genetic Epidemiology
Association of a Pvull RFLP at the lipoprotein lipase locus with fasting insulin levels in Hispanic men
Why the study?
Is the LPL PvuII genotype associated with fasting insulin and lipid levels in Hispanic men and women?
Population
199 Hispanic individuals (102 men, 97 women)
Comparison
Lipoprotein lipase (LPL) PvuII genotypes vs Different LPL PvuII genotypes compared to each…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Should not change practice; leaves open sex-specific LPL effects on insulin regulation in Hispanics.
Structured PICO
Is the LPL PvuII genotype associated with fasting insulin and lipid levels in Hispanic men and women?
P
Population
199 Hispanic individuals (102 men, 97 women)
I
Intervention
Lipoprotein lipase (LPL) PvuII genotypes
C
Comparator
Different LPL PvuII genotypes (+/+, +/-, -/-) compared to each other
O
Outcome
Fasting insulin levels and lipid levels (fasting serum triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol, HDL2/HDL3-cholesterol)surrogate
The LPL PvuII genotype is associated with fasting insulin levels in Hispanic men, suggesting genotype-specific regulation of LPL by insulin.
Cite This Study
Cole et al. (1993) studied this question.