January 1, 2004Diabetes
Lipoprotein Lipase Is a Gene for Insulin Resistance in Mexican Americans
Why the study?
Is variation in the lipoprotein lipase (LPL) gene associated with insulin resistance in Mexican Americans?
Population
Large family-based population of Mexican Americans
Comparison
Lipoprotein lipase gene haplotypes defined by… vs Comparison between different LPL haplotypes
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
LPL variation may associate with insulin resistance in Mexican Americans; leaves open causal role, generalizability, and clinical utility.
Structured PICO
Is variation in the lipoprotein lipase (LPL) gene associated with insulin resistance in Mexican Americans?
P
Population
Large family-based population of Mexican Americans
I
Intervention
Lipoprotein lipase (LPL) gene haplotypes defined by six polymorphisms
C
Comparator
Comparison between different LPL haplotypes (e.g., haplotype 1 vs. haplotype 4)
O
Outcome
Glucose infusion rate (GINF) measured by hyperinsulinemic-euglycemic clampsurrogate
Variation in the LPL gene is significantly associated with insulin resistance in Mexican Americans, providing a genetic link to this cardiovascular risk factor.
Cite This Study
Goodarzi et al. (2004) studied this question.